TY - JOUR
T1 - The Toxicology Investigators Consortium Case Registry—the 2021 Annual Report
AU - On behalf of the Toxicology Investigators Consortium Study Group
AU - Love, Jennifer S.
AU - Karshenas, Dana L.
AU - Spyres, Meghan B.
AU - Farrugia, Lynn A.
AU - Kang, A. Min
AU - Nguyen, Hoan Vu
AU - Campleman, Sharan L.
AU - Li, Shao
AU - Wax, Paul M.
AU - Brent, Jeffery
AU - Aldy, Kim
AU - Abesamis, Michael
AU - Acciani, Jennifer
AU - Adeyeye, Elizabeth
AU - Adkins, Alek
AU - Akpunonu, Peter
AU - Al Balushi, Hassan
AU - Albertson, Timothy
AU - Algren, Adam
AU - Amaducci, Alexandra
AU - Archer, John
AU - Avera, Robert
AU - Babu, Kavita
AU - Baker, Keith
AU - Baumgartner, Kevin
AU - Bearlin, Noah
AU - Beauchamp, Gillian
AU - Bebarta, Vik
AU - Betting, David
AU - Beuhler, Michael
AU - Bird, Steven
AU - Blundell, Matthew
AU - Boroughf, William
AU - Bourgeois, Kayla
AU - Boyle, Katherine
AU - Bradley, Evan
AU - Brambl, Wells
AU - Brandehoff, Nicklaus
AU - Brenner, Marielle
AU - Brooks, Daniel
AU - Buchanan, Jennie
AU - Burns, Michele
AU - Cahana, Alfred
AU - Caja, Kevin
AU - Calello, Diane
AU - Calleo, Vince
AU - Camarena-Michel, Alexa
AU - Canning, Joshua
AU - Cannon, Robert
AU - Kirschner, Ronald
N1 - Publisher Copyright:
© 2022, American College of Medical Toxicology.
PY - 2022/10
Y1 - 2022/10
N2 - The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core Registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultations will be entered. This twelfth annual report summarizes the registry’s 2021 data and activity with its additional 8552 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2021. Detailed data was collected from these cases and aggregated to provide information, which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.4% of cases in females, 48.2% of cases in males, and 1.4% of cases in transgender or gender non-conforming individuals. Non-opioid analgesics were the most commonly reported agent class (14.9%), followed by opioids (13.1%). Acetaminophen was the most common agent reported. Fentanyl was the most common opioid reported and was responsible for the greatest number of fatalities. There were 120 fatalities, comprising 1.4% of all cases. Major trends in demographics and exposure characteristics remained similar to past years’ reports. Sub-analyses were conducted to describe new demographic characteristics, including marital status, housing status and military service, the continued COVID-19 pandemic and related toxicologic exposures, and novel substances of exposure.
AB - The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core Registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultations will be entered. This twelfth annual report summarizes the registry’s 2021 data and activity with its additional 8552 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2021. Detailed data was collected from these cases and aggregated to provide information, which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.4% of cases in females, 48.2% of cases in males, and 1.4% of cases in transgender or gender non-conforming individuals. Non-opioid analgesics were the most commonly reported agent class (14.9%), followed by opioids (13.1%). Acetaminophen was the most common agent reported. Fentanyl was the most common opioid reported and was responsible for the greatest number of fatalities. There were 120 fatalities, comprising 1.4% of all cases. Major trends in demographics and exposure characteristics remained similar to past years’ reports. Sub-analyses were conducted to describe new demographic characteristics, including marital status, housing status and military service, the continued COVID-19 pandemic and related toxicologic exposures, and novel substances of exposure.
KW - Epidemiology
KW - Medical toxicology
KW - Overdose
KW - Poisoning
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85137431288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137431288&partnerID=8YFLogxK
U2 - 10.1007/s13181-022-00910-6
DO - 10.1007/s13181-022-00910-6
M3 - Article
C2 - 36070069
AN - SCOPUS:85137431288
SN - 1556-9039
VL - 18
SP - 267
EP - 296
JO - Journal of Medical Toxicology
JF - Journal of Medical Toxicology
IS - 4
ER -