The Transcribed-Ultra Conserved Regions: Novel non-coding RNA players in neuroblastoma progression

Nithya Mudgapalli, Brianna P. Shaw, Srinivas Chava, Kishore B. Challagundla

Research output: Contribution to journalReview article

Abstract

The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of evidence suggests that T-UCRs contribute to oncogenic pathways. Neuroblastoma is a type of childhood cancer that is challenging to treat. The role of non-coding RNAs in the pathogenesis of neuroblastoma, in particular for cancer development, progression, and therapy resistance, has been documented. Exosmic non-coding RNAs are also involved in shaping the biology of the tumor microenvironment in neuroblastoma. In recent years, the involvement of T-UCRs in a wide variety of pathways in neuroblastoma has been discovered. Here, we present an overview of the involvement of T-UCRs in various cellular pathways, such as DNA damage response, proliferation, chemotherapy response, MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)) amplification, gene copy number, and immune response, as well as correlate it to patient survival in neuroblastoma.

Original languageEnglish (US)
Article number39
JournalNon-coding RNA
Volume5
Issue number2
DOIs
StatePublished - 2019

Keywords

  • Biomarkers
  • Exosomes
  • MYCN
  • Metastasis
  • MicroRNAs
  • Neuroblastoma
  • Oncogenes
  • Therapy resistance
  • Transcribed-ultra conserved regions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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