The transcription factor STAT5 is critical in dendritic cells for the development of TH 2 but not TH 1 responses

Bryan D. Bell, Masayuki Kitajima, Ryan P. Larson, Thomas A. Stoklasek, Kristen Dang, Kazuhito Sakamoto, Kay Uwe Wagner, Boris Reizis, Lothar Hennighausen, Steven F. Ziegler

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T Helper type 2 (TH 2), but not TH 1, allergic responses in both the skin and lungs. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of the expression of costimulatory molecules and chemokine production. Furthermore, TH 2 responses in mice with DC-specific loss of STAT5 resembled those seen in mice deficient in the receptor for TSLP. Our results show that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 2 immunity at barrier surfaces.

Original languageEnglish (US)
Pages (from-to)364-371
Number of pages8
JournalNature Immunology
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Bell, B. D., Kitajima, M., Larson, R. P., Stoklasek, T. A., Dang, K., Sakamoto, K., Wagner, K. U., Reizis, B., Hennighausen, L., & Ziegler, S. F. (2013). The transcription factor STAT5 is critical in dendritic cells for the development of TH 2 but not TH 1 responses. Nature Immunology, 14(4), 364-371. https://doi.org/10.1038/ni.2541