The treatment of restless legs syndrome and periodic limb movement disorder in adults - An update for 2012: Practice parameters with an evidence-based systematic review and meta-analyses

R. Nisha Aurora, David A. Kristo, Sabin R. Bista, James A. Rowley, Rochelle S. Zak, Kenneth R. Casey, Carin I. Lamm, Sharon L. Tracy, Richard S. Rosenberg

Research output: Contribution to journalReview article

204 Scopus citations

Abstract

A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a ST ANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supplementation. The committee recommends a ST ANDARD AGAINST the use of pergolide because of the risks of heart valve damage. Therapies for RLS secondary to ESRD, neuropathy, and superficial venous insufficiency are discussed. Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS.

Original languageEnglish (US)
Pages (from-to)1039-1062
Number of pages24
JournalSleep
Volume35
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • PLMD
  • Periodic limb movement disorder
  • RLS
  • Restless legs syndrome
  • Sleep-related movement disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

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