The Triplo-lethal locus of Drosophila: Reexamination of mutants and discovery of a second-site suppressor

D. R. Dorer, D. H. Ezekiel, A. C. Christensen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In the genome of Drosophila melanogaster there is a single locus, Triplo- lethal (Tpl), that causes lethality when present in either one or three copies in an otherwise diploid animal. Previous attempts to mutagenize Tpl produced alleles that were viable over a chromosome bearing a duplication of Tpl, but were not lethal in combination with a wild-type chromosome, as deficiencies for Tpl are. These mutations were interpreted as hypomorphic alleles of Tpl. In this work, we show that these alleles are not mutations at Tpl; rather, they are dominant mutations in a tightly linked, but cytologically distant, locus that we have named Suppressor-of-Tpl (Su(Tpl)). Su(Tpl) mutations suppress the lethality associated with three copies of the Triplo-lethal locus and are recessive lethal. We have mapped Su(Tpl) to the approximate map position 3-46.5, within the cytological region 76B-76D.

Original languageEnglish (US)
Pages (from-to)1037-1042
Number of pages6
JournalGenetics
Volume141
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Genetics

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