The ubiquitin-proteasome system and cardiovascular disease

Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

58 Scopus citations

Abstract

Over the past decade, the role of the ubiquitin-proteasome system (UPS) has been the subject of numerous studies to elucidate its role in cardiovascular physiology and pathophysiology. There have been many advances in this field including the use of proteomics to achieve a better understanding of how the cardiac proteasome is regulated. Moreover, improved methods for the assessment of UPS function and the development of genetic models to study the role of the UPS have led to the realization that often the function of this system deviates from the norm in many cardiovascular pathologies. Hence, dysfunction has been described in atherosclerosis, familial cardiac proteinopathies, idiopathic dilated cardiomyopathies, and myocardial ischemia. This has led to numerous studies of the ubiquitin protein (E3) ligases and their roles in cardiac physiology and pathophysiology. This has also led to the controversial proposition of treating atherosclerosis, cardiac hypertrophy, and myocardial ischemia with proteasome inhibitors. Furthering our knowledge of this system may help in the development of new UPS-based therapeutic modalities for mitigation of cardiovascular disease.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages295-346
Number of pages52
DOIs
StatePublished - 2012

Publication series

NameProgress in Molecular Biology and Translational Science
Volume109
ISSN (Print)1877-1173

Keywords

  • Atherosclerosis
  • Cardiomyopathy
  • Heart
  • Heart failure
  • Myocardial ischemia
  • Preconditioning
  • Protein quality control
  • Ubiquitin protein ligases
  • Ubiquitin-proteasome system
  • Vascular

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Powell, S. R., Herrmann, J., Lerman, A., Patterson, C., & Wang, X. (2012). The ubiquitin-proteasome system and cardiovascular disease. In Progress in Molecular Biology and Translational Science (pp. 295-346). (Progress in Molecular Biology and Translational Science; Vol. 109). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-397863-9.00009-2