The University of Michigan Dioxin Exposure Study: Methods for an environmental exposure study of polychlorinated dioxins, furans, and biphenyls

David H. Garabrant, Alfred Franzblau, James Lepkowski, Brenda W. Gillespie, Peter Andriaens, Avery Demond, Barbara Ward, Kathy LaDronka, Elizabeth Hedgeman, Kristine Knutson, Lynn Zwica, Kristen Olson, Timothy Towey, Qixuan Chen, Biling Hong

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: The University of Michigan Dioxin Exposure Study (UMDES) was undertaken in response to concerns that the discharge of dioxin-like compounds from the Dow Chemical Company facilities in Midland, Michigan, resulted in contamination of soils in the Tittabawassee River floodplain and areas of the city of Midland, leading to an increase in residents' body burdens of polychlorinated dibenzodioxins and polychlorinated dibenzofurans. Objectives: The UMDES is a hypothesis-driven study designed to answer important questions about human exposure to dioxins in the environment of Midland, where the Dow Chemical Company has operated for > 100 years, and in neighboring Saginaw, Michigan. In addition, the UMDES includes a referent population from an area of Michigan in which there are no unusual sources of dioxin exposure and from which inferences regarding the general Michigan population can be derived. A central goal of the study is to determine which factors explain variation in serum dioxin levels and to quantify how much variation each factor explains. Conclusions: In this article we describe the study design and methods for a large population-based study of dioxin contamination and its relationship to blood dioxin levels. The study collected questionnaire, blood, dust, and soil samples on 731 people. This study provides a foundation for understanding the exposure pathways by which dioxins in soils, sediments, fish and game, and homegrown produce lead to increased body burdens of these compounds.

Original languageEnglish (US)
Pages (from-to)803-810
Number of pages8
JournalEnvironmental Health Perspectives
Volume117
Issue number5
DOIs
StatePublished - Jun 9 2009

Keywords

  • Biomonitoring
  • Diet
  • Dioxins
  • Environmental exposure
  • Epidemiology
  • Population-based
  • Serum
  • Soil
  • Survey

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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  • Cite this

    Garabrant, D. H., Franzblau, A., Lepkowski, J., Gillespie, B. W., Andriaens, P., Demond, A., Ward, B., LaDronka, K., Hedgeman, E., Knutson, K., Zwica, L., Olson, K., Towey, T., Chen, Q., & Hong, B. (2009). The University of Michigan Dioxin Exposure Study: Methods for an environmental exposure study of polychlorinated dioxins, furans, and biphenyls. Environmental Health Perspectives, 117(5), 803-810. https://doi.org/10.1289/ehp.11777