The use of prostaglandin E1 in a critically ill infant with transposition of the great arteries

D. J. Driscoll, J. D. Kugler, M. R. Nihill, D. G. McNamara

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Continuous prostaglandin E1 infusion temporarily maintains patency of the ductus arteriosus in infants for periods ranging from a few hours to several days. This can be lifesaving in neonatal patients awaiting surgical palliation for the type of congenital cardiac defects in which blood flow to the lungs depends on a patent ductus arteriosus. Moreover, prostaglandin E1 infusion can be used to stabilize critically ill infants with coarctation of the aorta in whom blood flow to the descending aorta is dependent upon a patent ductus arteriosus. Recently, we infused prostaglandin E1 into an infant with d-transposition of the great arteries who remained severely hypoxemic despite seemingly adequate balloon atrial septostomy. Prostaglandin E1 infusion was associated with a prompt increase of arterial blood oxygen saturation.

Original languageEnglish (US)
Pages (from-to)259-261
Number of pages3
JournalJournal of Pediatrics
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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