Continuous prostaglandin E1 infusion temporarily maintains patency of the ductus arteriosus in infants for periods ranging from a few hours to several days. This can be lifesaving in neonatal patients awaiting surgical palliation for the type of congenital cardiac defects in which blood flow to the lungs depends on a patent ductus arteriosus. Moreover, prostaglandin E1 infusion can be used to stabilize critically ill infants with coarctation of the aorta in whom blood flow to the descending aorta is dependent upon a patent ductus arteriosus. Recently, we infused prostaglandin E1 into an infant with d-transposition of the great arteries who remained severely hypoxemic despite seemingly adequate balloon atrial septostomy. Prostaglandin E1 infusion was associated with a prompt increase of arterial blood oxygen saturation.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health