The use of tandem mass spectrometry for the structure determination of adducts formed between dna and dibenzo[a, l]pyrene

Ronald L. Cerny, Joelle M.Y. Wellemans, Mathai George, Michael L. Gross

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Tandem mass spectrometry was used in the structure determinations of adducts formed between nucleosides and the potent carcinogen dibenzo[a,l]pyrene. Adducts expected to arise from both the one-electron oxidation mechanism and by the diol epoxide mechanism were studied. Structural isomers of the adducts can be distinguished by the fragment ions observed in their respective collisionally activated decomposition (CAD) spectra.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalPolycyclic Aromatic Compounds
Volume6
Issue number1-4
DOIs
StatePublished - Jan 1994

Keywords

  • FAB
  • MS/MS
  • PAH-DNA adducts
  • mass spectrometry

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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