The use of tandem mass spectrometry for the structure determination of adducts formed between dna and dibenzo[a, l]pyrene

Ronald L. Cerny; Joelle M.Y. Wellemans; Mathai George; Michael L. Gross

doi:10.1080/10406639408031187

The use of tandem mass spectrometry for the structure determination of adducts formed between dna and dibenzo[a, l]pyrene

Ronald L. Cerny, Joelle M.Y. Wellemans, Mathai George, Michael L. Gross

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Tandem mass spectrometry was used in the structure determinations of adducts formed between nucleosides and the potent carcinogen dibenzo[a,l]pyrene. Adducts expected to arise from both the one-electron oxidation mechanism and by the diol epoxide mechanism were studied. Structural isomers of the adducts can be distinguished by the fragment ions observed in their respective collisionally activated decomposition (CAD) spectra.

Original language	English (US)
Pages (from-to)	215-222
Number of pages	8
Journal	Polycyclic Aromatic Compounds
Volume	6
Issue number	1-4
DOIs	https://doi.org/10.1080/10406639408031187
State	Published - Jan 1994

Keywords

FAB
MS/MS
PAH-DNA adducts
mass spectrometry

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1080/10406639408031187

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abstract = "Tandem mass spectrometry was used in the structure determinations of adducts formed between nucleosides and the potent carcinogen dibenzo[a,l]pyrene. Adducts expected to arise from both the one-electron oxidation mechanism and by the diol epoxide mechanism were studied. Structural isomers of the adducts can be distinguished by the fragment ions observed in their respective collisionally activated decomposition (CAD) spectra.",

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AU - George, Mathai

AU - Gross, Michael L.

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N2 - Tandem mass spectrometry was used in the structure determinations of adducts formed between nucleosides and the potent carcinogen dibenzo[a,l]pyrene. Adducts expected to arise from both the one-electron oxidation mechanism and by the diol epoxide mechanism were studied. Structural isomers of the adducts can be distinguished by the fragment ions observed in their respective collisionally activated decomposition (CAD) spectra.

AB - Tandem mass spectrometry was used in the structure determinations of adducts formed between nucleosides and the potent carcinogen dibenzo[a,l]pyrene. Adducts expected to arise from both the one-electron oxidation mechanism and by the diol epoxide mechanism were studied. Structural isomers of the adducts can be distinguished by the fragment ions observed in their respective collisionally activated decomposition (CAD) spectra.

KW - FAB

KW - MS/MS

KW - PAH-DNA adducts

KW - mass spectrometry

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The use of tandem mass spectrometry for the structure determination of adducts formed between dna and dibenzo[a, l]pyrene

Abstract

Keywords

ASJC Scopus subject areas

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