Abstract
Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 496-502 |
| Number of pages | 7 |
| Journal | Clinical Infectious Diseases |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 15 2015 |
Keywords
- Ebola virus
- Ebola virus disease
- TKM-Ebola
- convalescent plasma
- convalescent serum
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
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In: Clinical Infectious Diseases, Vol. 61, No. 4, 15.08.2015, p. 496-502.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States
AU - Kraft, Colleen S.
AU - Hewlett, Angela L
AU - Koepsell, Scott A
AU - Winkler, Anne M.
AU - Kratochvil, Christopher J
AU - Larson, Luann
AU - Varkey, Jay B.
AU - Mehta, Aneesh K.
AU - Lyon, G. Marshall
AU - Friedman-Moraco, Rachel J.
AU - Marconi, Vincent C.
AU - Hill, Charles E.
AU - Sullivan, James N
AU - Johnson, Daniel W
AU - Lisco, Steven J
AU - Mulligan, Mark J.
AU - Uyeki, Timothy M.
AU - McElroy, Anita K.
AU - Sealy, Tara
AU - Campbell, Shelley
AU - Spiropoulou, Christina
AU - Ströher, Ute
AU - Crozier, Ian
AU - Sacra, Richard
AU - Connor, Michael J.
AU - Sueblinvong, Viranuj
AU - Franch, Harold A.
AU - Smith, Philip W.
AU - Ribner, Bruce S.
AU - Schwedhelm, Shelly
AU - Boulter, Kate
AU - Beam, Elizabeth L
AU - Gibbs, Shawn
AU - Lowe, John-Martin J
AU - Piquette, Craig Arnold
AU - Bailey, Kristina L
AU - Auxier, Joseph
AU - Boer, Brian
AU - Hanson, Travis
AU - Kaseman, Julia
AU - Khan, M. Salman
AU - Rhee, Ji Hyun
AU - Wells, Adam
AU - Florescu, Diana F
AU - Kalil, Andre C
AU - Rupp, Mark Edmund
AU - Becker, Valerie
AU - Boeckman, Bridget
AU - Elder, Erica
AU - Fitch, Abby
AU - Flood, Elizabeth
AU - Freml, Meagan
AU - Frigge, Roman
AU - Hanzlik, Kelly Ann
AU - Jensen, Lois
AU - Kraus, Nicole
AU - Molacek, Drew
AU - Nevins, Jerry
AU - Parker, Alicia
AU - Peters, Jeff
AU - Rand, Cheryl
AU - Roesler, Karen
AU - Ryalls, Kendall
AU - Shradar, Morgan
AU - Strain, Amanda
AU - Sunderman, Timothy
AU - Sundermeier, Jennifer
AU - Swanhorst, John
AU - Vasa, Angela
AU - Bellinghausen, Jean
AU - Freihaut, Frank
AU - Denny, Susan
AU - Mainelli, Lauren
AU - Pinkney, Dee
AU - Ray, Deborah
AU - Jevne, Jay
AU - Knight, Kalen
AU - McCroy, Derrick
AU - Nadeau, Ralph
AU - Nightser, Anna
AU - Iwen, Peter Charles
AU - Sambol, Tony
AU - Herrera, Vicki
AU - Morgan, David
AU - Trotter, Sarah
AU - Kerby, Amy
AU - Peters, Sue
AU - Southern, Timothy
AU - Murphy, Caitlin
AU - Morris, Rosanna
AU - Nuss, Suzanne
AU - Franco, Theresa
AU - Ogden, Connie
AU - Lazure, Julie
AU - Straub, Dawn
AU - Hinrichs, Steven Heye
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AU - Florescu, Marius C
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AU - Beck, Emily
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AU - Hall, Cynthia
AU - Walker, Celeste
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AU - Frisle, Brian
AU - Jackson, Robert
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AU - Gartin, Miranda Lynn
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AU - Stark, Dan
AU - McGee, Gentrice
AU - Jones, Porcia
AU - Scott-Harris, Linda
AU - Cain, James
AU - Davis, Roderick
AU - Johnson, Tyrone
AU - Pickett, Tyrone
AU - Shaw, Anthony
AU - Truesdale, Tenina
AU - Blum, Jim
AU - Hill, Laureen
AU - Sevransky, Jon
AU - Zivot, Joel
AU - Walker, Seth
AU - Klopman, Matthew
AU - Matkins, Ricky
AU - Meechan, Cathy
AU - Meechan, Paul
AU - Schwock, Kathy
AU - Schuck, Jen
AU - Stack, Kathy
AU - Wolf, Francis
AU - Bray, Bruce
AU - Isakov, Alex
AU - Shartar, Sam
AU - Miles, Wade
AU - Jamison, Aaro
AU - Arevalo, John
AU - Stallings, Gail
AU - Christenbury, Janet
AU - Dollard, Vince
AU - De Gennaro, Melanie
AU - Korschun, Holly
AU - Seideman, Nancy
AU - Ziegler, Tom
AU - Griffith, Daniel P.
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AU - Clarke, Tim
AU - Vaught, Rachel
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N1 - Publisher Copyright: © 2015 The Author 2015.
PY - 2015/8/15
Y1 - 2015/8/15
N2 - Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
AB - Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
KW - Ebola virus
KW - Ebola virus disease
KW - TKM-Ebola
KW - convalescent plasma
KW - convalescent serum
UR - http://www.scopus.com/inward/record.url?scp=84931448280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931448280&partnerID=8YFLogxK
U2 - 10.1093/cid/civ334
DO - 10.1093/cid/civ334
M3 - Article
C2 - 25904375
AN - SCOPUS:84931448280
SN - 1058-4838
VL - 61
SP - 496
EP - 502
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -