The use of two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF-MS) for metabolomic analysis of polar metabolites.

Kimberly Ralston-Hooper; Amber Jannasch; Jiri Adamec; Maria Sepúlveda

doi:10.1007/978-1-61737-985-7_12

The use of two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF-MS) for metabolomic analysis of polar metabolites.

Kimberly Ralston-Hooper, Amber Jannasch, Jiri Adamec, Maria Sepúlveda

Biochemistry

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Metabolites produced by an organism can be quite extensive, and one analytical technique alone is not capable of their comprehensive detection and identification. The majority of environmental metabolomic studies have implemented proton nuclear magnetic resonance ((1)H-NMR) spectroscopy with little attention given to mass spectrometry (MS) techniques. In this chapter, an analytical technique is outlined that incorporates two-dimensional gas chromatography-time-of-flight MS (GC×GC-TOF-MS) for the identification and quantification of polar metabolites.

Original language	English (US)
Pages (from-to)	205-211
Number of pages	7
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	708
DOIs	https://doi.org/10.1007/978-1-61737-985-7_12
State	Published - 2011

ASJC Scopus subject areas

Molecular Biology
Genetics

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Ralston-Hooper, K., Jannasch, A., Adamec, J., & Sepúlveda, M. (2011). The use of two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF-MS) for metabolomic analysis of polar metabolites. Methods in molecular biology (Clifton, N.J.), 708, 205-211. https://doi.org/10.1007/978-1-61737-985-7_12

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