The utilization of intravenously infused pyridoxine in humans

Janos Zempleni, Werner Kübler

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The utilization of a usual dose of intravenously infused pyridoxine (100 mg pyridoxine hydrochloride) was investigated in ten healthy males. Blood plasma and erythrocytes were investigated by means of high-performance liquid chromatography. Detectable metabolites in blood plasma were pyridoxine, pyridoxal 5'-phosphate, pyridoxal and 4-pyridoxic acid. In erythrocytes pyridoxine, pyridoxal 5'-phosphate, pyridoxal, and pyridoxamine 5'-phosphate were found. From their concentration-time curves rate constants of elimination and invasion, volume of distribution (pyridoxine) and the areas under the curves were calculated. Values for concmax and tmax are reported. A comparison with earlier results of oral pyridoxine administration revealed a better utilization after intravenous than after oral application, i.e. a greater build-up of coenzyme forms. A regulatory phenomenon in erythrocytes caused by high doses of pyridoxine is described. In view of the potential toxicity of pyridoxine the doses used in parenteral nutrition are called into question.

Original languageEnglish (US)
Pages (from-to)27-36
Number of pages10
JournalClinica Chimica Acta
Volume229
Issue number1-2
DOIs
StatePublished - Sep 1994

Keywords

  • Humans
  • Intravenous infusion
  • Metabolism
  • Pharmacokinetics
  • Pyridoxine
  • Utilization

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'The utilization of intravenously infused pyridoxine in humans'. Together they form a unique fingerprint.

  • Cite this