TY - JOUR
T1 - The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations
T2 - the Case of COMPLETE and the T-Cell Project
AU - Bellei, Monica
AU - Nabhan, Chadi
AU - Pesce, Emanuela Anna
AU - Conte, Luana
AU - Vose, Julie M.
AU - Foss, Francine
AU - Federico, Massimo
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies that portend a poor prognosis and have an undefined optimal therapeutic strategy. Data on best practices stem from prior studies that have generally included B cell lymphomas. However, the enhanced ability to diagnose PTCLs, the development of newer agents specific for PTCLs, and its increased incidence have called the scientific community to develop better strategies to combat these neoplasms. To that end, T cell lymphoma registries were developed in an attempt to answer relevant questions on the prognosis and management of PTCLs. The largest registries currently enrolling patients are the Comprehesive Oncology Measures for PeripheraL T-cEll Lymphoma TrEatment (COMPLETE) and the T-Cell Project. Despite the inherent limitations of these studies, valuable information are being collected to refine our management approaches and to aid in designing future clinical trials. This review illustrates the value of these registries and describes the critical questions that need to be answered.
AB - Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies that portend a poor prognosis and have an undefined optimal therapeutic strategy. Data on best practices stem from prior studies that have generally included B cell lymphomas. However, the enhanced ability to diagnose PTCLs, the development of newer agents specific for PTCLs, and its increased incidence have called the scientific community to develop better strategies to combat these neoplasms. To that end, T cell lymphoma registries were developed in an attempt to answer relevant questions on the prognosis and management of PTCLs. The largest registries currently enrolling patients are the Comprehesive Oncology Measures for PeripheraL T-cEll Lymphoma TrEatment (COMPLETE) and the T-Cell Project. Despite the inherent limitations of these studies, valuable information are being collected to refine our management approaches and to aid in designing future clinical trials. This review illustrates the value of these registries and describes the critical questions that need to be answered.
KW - COMPLETE
KW - Peripheral T cell lymphomas
KW - T cell lymphoma registries
KW - T-Cell Project
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U2 - 10.1007/s11899-015-0291-0
DO - 10.1007/s11899-015-0291-0
M3 - Review article
C2 - 26449717
AN - SCOPUS:84949536731
SN - 1558-8211
VL - 10
SP - 448
EP - 455
JO - Current Hematologic Malignancy Reports
JF - Current Hematologic Malignancy Reports
IS - 4
ER -