The value of HIV protective epitope research for informed vaccine design against diverse viral pathogens

Victor G. Kramer; Siddappa N. Byrareddy

doi:10.1586/14760584.2014.928597

The value of HIV protective epitope research for informed vaccine design against diverse viral pathogens

Victor G. Kramer, Siddappa N. Byrareddy

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate design. The strategies employed for identification of HIV protective epitopes will also aid towards rational vaccine design for other viral pathogens.

Original language	English (US)
Pages (from-to)	935-937
Number of pages	3
Journal	Expert Review of Vaccines
Volume	13
Issue number	8
DOIs	https://doi.org/10.1586/14760584.2014.928597
State	Published - Aug 2014
Externally published	Yes

Keywords

Epitope
Glycan
H1N1
HIV
Vaccine

ASJC Scopus subject areas

Immunology
Molecular Medicine
Pharmacology
Drug Discovery

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10.1586/14760584.2014.928597

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title = "The value of HIV protective epitope research for informed vaccine design against diverse viral pathogens",

abstract = "The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate design. The strategies employed for identification of HIV protective epitopes will also aid towards rational vaccine design for other viral pathogens.",

keywords = "Epitope, Glycan, H1N1, HIV, Vaccine",

author = "Kramer, {Victor G.} and Byrareddy, {Siddappa N.}",

note = "Funding Information: This work was supported in part by grants from the NIH (R21 AI098581) to SN Byrareddy. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.",

year = "2014",

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AU - Byrareddy, Siddappa N.

N1 - Funding Information: This work was supported in part by grants from the NIH (R21 AI098581) to SN Byrareddy. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

PY - 2014/8

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N2 - The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate design. The strategies employed for identification of HIV protective epitopes will also aid towards rational vaccine design for other viral pathogens.

AB - The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate design. The strategies employed for identification of HIV protective epitopes will also aid towards rational vaccine design for other viral pathogens.

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KW - Glycan

KW - H1N1

KW - HIV

KW - Vaccine

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The value of HIV protective epitope research for informed vaccine design against diverse viral pathogens

Abstract

Keywords

ASJC Scopus subject areas

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