The viral potassium channel Kcv: Structural and functional features

Sabrina Gazzarrini, Maria Severino, Mara Lombardi, Marzia Morandi, Dario DiFrancesco, James L. Van Etten, Gerhard Thiel, Anna Moroni

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalFEBS Letters
Volume552
Issue number1
DOIs
StatePublished - Sep 18 2003

Keywords

  • Chlorella virus
  • K channel
  • Kcv
  • PBCV-1

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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