Therapeutic leukocytapheresis for leukostasis in chronic lymphocytic leukemia: A case report and literature review

Thomas Auen, Pranav Renavikar, Esther Habib, Scott A. Koepsell

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic lymphocytic leukemia (CLL) is a clonal mature B-cell neoplasm with a typically indolent clinical course. Though most clinicians follow these neoplasms through observation alone, an aggressive transformation to prolymphocytic leukemia, diffuse large-B-cell lymphoma (Richter transformation) or classical Hodgkin lymphoma requires immediate attention. We present a case of extreme leukocytosis (>1 million/μL) in a previously diagnosed CLL patient. Due to symptomatic leukostasis, she was started on cytoreductive therapies including leukocytapheresis. After three rounds of leukocytapheresis (LCP) and concurrent chemotherapy, her white blood cell count decreased from a maximum 1262 × 103/μL to 574 × 103/μL. To our knowledge, CLL with symptomatic leukostasis that required therapeutic LCP is rarely reported in literature. We propose that therapeutic LCP is of value in such rare, yet dangerous settings like our case.

Original languageEnglish (US)
Pages (from-to)764-769
Number of pages6
JournalJournal of Clinical Apheresis
Volume38
Issue number6
DOIs
StatePublished - Dec 2023
Externally publishedYes

Keywords

  • hyperleukocytosis
  • leukocytosis
  • lymphocytes
  • symptomatic
  • viscosity
  • white blood cell

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Therapeutic leukocytapheresis for leukostasis in chronic lymphocytic leukemia: A case report and literature review'. Together they form a unique fingerprint.

Cite this