Therapeutic options for rheumatoid arthritis

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Background: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder primarily targeting the synovium. Unchecked disease activity is associated with significant morbidity and an increased mortality. Recent advances in the understanding of the pathogenesis of RA and the capability of biologically engineered treatments for RA have expanded the armamentarium of antirheumatic agents. Methods: A systematic literature review was conducted through PubMed. Results/conclusions: At present, a common strategy for the treatment of RA uses methotrexate either as monotherapy or in combination with a variety of conventional and/or biologic disease-modifying antirheumatic drugs (DMARDs), with the goal of inducing remission of active disease. The choice of which agent(s) to use is based upon patient-specific criteria (activity of disease, comorbidities, patient preferences, costs etc.). Emerging therapies that target specific cytokines and growth factors in the inflammatory cascade of RA offer a potent new means of modifying disease activity, but many questions regarding their use remain unanswered.

Original languageEnglish (US)
Pages (from-to)2095-2106
Number of pages12
JournalExpert Opinion on Pharmacotherapy
Volume10
Issue number13
DOIs
StatePublished - Sep 2009

Keywords

  • Abatacept
  • Adalimumab
  • Anakinra
  • Azathioprine
  • DMARDS
  • Etanercept
  • Hydroxychloroquine
  • Infliximab
  • Leflunomide
  • Methotrexate
  • Rheumatoid arthritis
  • Rituximab
  • Sulfasalazine
  • Tumor necrosis factor-alpha (TNF-α) inhibitors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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