Therapeutic studies in NZB/NZW mice.

Alfred D. Steinberg; Randall Krakauer; James L. Reinertsen; Lynell W. Klassen; David Ilfeld; J. Patton Reeves; Gary W. Williams; Tatiana Antonovych

doi:10.1002/art.1780210205

Therapeutic studies in NZB/NZW mice.

Alfred D. Steinberg, Randall Krakauer, James L. Reinertsen, Lynell W. Klassen, David Ilfeld, J. Patton Reeves, Gary W. Williams, Tatiana Antonovych

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Spleen cells from normal mice were cultured with Concanavalin A to produce an immunosuppressive supernate. This supernate was used to treat the lupus‐like autoimmune disease of NZB/NZW mice. Such treated mice lived significantly longer than did controls, but only if treatment was initiated early in the course of the illness.

Original language	English (US)
Pages (from-to)	204-209
Number of pages	6
Journal	Arthritis & Rheumatism
Volume	21
Issue number	2
DOIs	https://doi.org/10.1002/art.1780210205
State	Published - Mar 1978
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780210205

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title = "Therapeutic studies in NZB/NZW mice.",

abstract = "Spleen cells from normal mice were cultured with Concanavalin A to produce an immunosuppressive supernate. This supernate was used to treat the lupus‐like autoimmune disease of NZB/NZW mice. Such treated mice lived significantly longer than did controls, but only if treatment was initiated early in the course of the illness.",

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AU - Ilfeld, David

AU - Reeves, J. Patton

AU - Williams, Gary W.

AU - Antonovych, Tatiana

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