Therapeutic targets to reduce cardiovascular disease in type 2 diabetes

Cyrus DeSouza, Vivian Fonseca

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The potential cardiovascular risks that are associated with drugs for type 2 diabetes have recently raised considerable clinical and regulatory concerns. As some risk factors for cardiovascular disease and type 2 diabetes are related, identifying agents that target shared underlying pathways and processes is an attractive therapeutic strategy. In this article, we review the background to and the implications of recent regulatory guidance on the development of new drugs for diabetes, and discuss the potential cardiovascular effects of selected classes of diabetes drugs that are currently being investigated.

Original languageEnglish (US)
Pages (from-to)361-367
Number of pages7
JournalNature Reviews Drug Discovery
Issue number5
StatePublished - 2009

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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