Therapeutic ultrasound for gene delivery

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

In vitro and in vivo studies using perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles to enhance gene delivery are reviewed. In vitro studies show PESDA binds to oligonucleotides and that ultrasound can be used to deposit these nucleotides. In addition, in vitro studies show that drug release from microspheres is dependent on ultrasound transmission frequency as well as pulsed or continuous application. Early in vivo studies confirm that ultrasound in combination with microbubbles can be used to facilitate gene deposition. However, the role of ultrasound targeting gene delivery remains to be determined.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalEchocardiography
Volume18
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Gene therapy
  • Microbubbles
  • Oligonucleotides
  • PESDA
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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