Therapeutic Uses of Contrast Microbubbles

Research output: Contribution to journalReview article

Abstract

Purpose of Review: The potential for non-invasive targeted delivery of therapeutic agents and targeted thrombus dissolution using diagnostic ultrasound (DUS) and intravenous microbubbles or droplets is an emerging technology that will change diagnostic ultrasound systems into therapeutic devices. Recent Findings: Targeted ultrasound destruction of microbubbles which carry either DNA or inhibitor RNA sequences have been utilized to both promote microvascular regeneration in ischemic myocardium and skeletal muscle and inhibit vascular growth in murine models of carcinoma. Targeted ultrasound microbubble cavitation has been utilized to improve ischemic limb blood flow via nitric oxide pathways and to induce targeted coronary and microvascular recanalization in large animal models of acute ST segment elevation myocardial infarction (STEMI). Summary: Initial clinical trials utilizing DUS and commercially available microbubbles in acute STEMI patients prior to, and after, emergent percutaneous coronary intervention have demonstrated the feasibility and efficacy of this approach in preserving microvascular flow.

Original languageEnglish (US)
Article number24
JournalCurrent Cardiovascular Imaging Reports
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • Diagnostic ultrasound
  • Mechanical index
  • Microbubbles
  • Targeted therapy

ASJC Scopus subject areas

  • Histology
  • Applied Microbiology and Biotechnology
  • Cell Biology

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