Therapies for neovascular age-related macular degeneration: Current approaches and pharmacologic agents in development

Mostafa Hanout, Daniel Ferraz, Mehreen Ansari, Natasha Maqsood, Saleema Kherani, Yasir J. Sepah, Nithya Rajagopalan, Mohamed Ibrahim, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

As one of the leading causes of blindness, age-related macular degeneration (AMD) has remained at the epicenter of clinical research in ophthalmology. During the past decade, focus of researchers has ranged from understanding the role of vascular endothelial growth factor (VEGF) in the angiogenic cascades to developing new therapies for retinal vascular diseases. Anti-VEGF agents such as ranibizumab and aflibercept are becoming increasingly well-established therapies and have replaced earlier approaches such as laser photocoagulation or photodynamic therapy. Many other new therapeutic agents, which are in the early phase clinical trials, have shown promising results. The purpose of this paper is to briefly review the available treatment modalities for neovascular AMD and then focus on promising new therapies that are currently in various stages of development.

Original languageEnglish (US)
Article number830837
JournalBioMed research international
Volume2013
DOIs
StatePublished - Dec 16 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Hanout, M., Ferraz, D., Ansari, M., Maqsood, N., Kherani, S., Sepah, Y. J., Rajagopalan, N., Ibrahim, M., Do, D. V., & Nguyen, Q. D. (2013). Therapies for neovascular age-related macular degeneration: Current approaches and pharmacologic agents in development. BioMed research international, 2013, [830837]. https://doi.org/10.1155/2013/830837