Therapy of Autochthonous Skin Cancers in Mice with Intravenously Injected Liposomes Containing Muramyltripeptide1

J. E. Talmadge; B. F. Lenz; R. Klabansky; C. Riggs; S. Guo; R. Simon; R. K. Oldham; I. J. Fidler

Therapy of Autochthonous Skin Cancers in Mice with Intravenously Injected Liposomes Containing Muramyltripeptide1

J. E. Talmadge, B. F. Lenz, R. Klabansky, C. Riggs, S. Guo, R. Simon, R. K. Oldham, I. J. Fidler

Research output: Contribution to journal › Article › peer-review

Abstract

Liposomes containing the immunomodulator muramyltripep-tide phosphatidylethanolamine (MTP-PE) or free saline were injected i.v. into BALB/c mice with autochthonous skin cancers induced by chronic exposure to ultraviolet irradiation. Treatment with liposomes containing MTP-PE produced significant retardation in the growth of the primary autochthonous skin cancers and significantly prolonged survival of the treated mice as compared with the saline-treated controls. Since ultraviolet-irradiated mice have a defect in immunological recognition of their autochthonous tumors, the therapeutic effects of liposomes containing MTP-PE are very encouraging. These results suggest that liposomes containing MTP-PE could be used for the treatment of patients with skin cancer or other malignant diseases.

Original language	English (US)
Pages (from-to)	1160-1163
Number of pages	4
Journal	Cancer Research
Volume	46
Issue number	3
State	Published - Mar 1 1986
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Therapy of Autochthonous Skin Cancers in Mice with Intravenously Injected Liposomes Containing Muramyltripeptide1",

abstract = "Liposomes containing the immunomodulator muramyltripep-tide phosphatidylethanolamine (MTP-PE) or free saline were injected i.v. into BALB/c mice with autochthonous skin cancers induced by chronic exposure to ultraviolet irradiation. Treatment with liposomes containing MTP-PE produced significant retardation in the growth of the primary autochthonous skin cancers and significantly prolonged survival of the treated mice as compared with the saline-treated controls. Since ultraviolet-irradiated mice have a defect in immunological recognition of their autochthonous tumors, the therapeutic effects of liposomes containing MTP-PE are very encouraging. These results suggest that liposomes containing MTP-PE could be used for the treatment of patients with skin cancer or other malignant diseases.",

author = "Talmadge, {J. E.} and Lenz, {B. F.} and R. Klabansky and C. Riggs and S. Guo and R. Simon and Oldham, {R. K.} and Fidler, {I. J.}",

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volume = "46",

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AU - Talmadge, J. E.

AU - Lenz, B. F.

AU - Klabansky, R.

AU - Riggs, C.

AU - Guo, S.

AU - Simon, R.

AU - Oldham, R. K.

AU - Fidler, I. J.

PY - 1986/3/1

Y1 - 1986/3/1

N2 - Liposomes containing the immunomodulator muramyltripep-tide phosphatidylethanolamine (MTP-PE) or free saline were injected i.v. into BALB/c mice with autochthonous skin cancers induced by chronic exposure to ultraviolet irradiation. Treatment with liposomes containing MTP-PE produced significant retardation in the growth of the primary autochthonous skin cancers and significantly prolonged survival of the treated mice as compared with the saline-treated controls. Since ultraviolet-irradiated mice have a defect in immunological recognition of their autochthonous tumors, the therapeutic effects of liposomes containing MTP-PE are very encouraging. These results suggest that liposomes containing MTP-PE could be used for the treatment of patients with skin cancer or other malignant diseases.

AB - Liposomes containing the immunomodulator muramyltripep-tide phosphatidylethanolamine (MTP-PE) or free saline were injected i.v. into BALB/c mice with autochthonous skin cancers induced by chronic exposure to ultraviolet irradiation. Treatment with liposomes containing MTP-PE produced significant retardation in the growth of the primary autochthonous skin cancers and significantly prolonged survival of the treated mice as compared with the saline-treated controls. Since ultraviolet-irradiated mice have a defect in immunological recognition of their autochthonous tumors, the therapeutic effects of liposomes containing MTP-PE are very encouraging. These results suggest that liposomes containing MTP-PE could be used for the treatment of patients with skin cancer or other malignant diseases.

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Therapy of Autochthonous Skin Cancers in Mice with Intravenously Injected Liposomes Containing Muramyltripeptide1

Abstract

ASJC Scopus subject areas

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