Therapy of Autochthonous Skin Cancers in Mice with Intravenously Injected Liposomes Containing Muramyltripeptide1

J. E. Talmadge, B. F. Lenz, R. Klabansky, C. Riggs, S. Guo, R. Simon, R. K. Oldham, I. J. Fidler

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Liposomes containing the immunomodulator muramyltripep-tide phosphatidylethanolamine (MTP-PE) or free saline were injected i.v. into BALB/c mice with autochthonous skin cancers induced by chronic exposure to ultraviolet irradiation. Treatment with liposomes containing MTP-PE produced significant retardation in the growth of the primary autochthonous skin cancers and significantly prolonged survival of the treated mice as compared with the saline-treated controls. Since ultraviolet-irradiated mice have a defect in immunological recognition of their autochthonous tumors, the therapeutic effects of liposomes containing MTP-PE are very encouraging. These results suggest that liposomes containing MTP-PE could be used for the treatment of patients with skin cancer or other malignant diseases.

Original languageEnglish (US)
Pages (from-to)1160-1163
Number of pages4
JournalCancer Research
Volume46
Issue number3
StatePublished - Mar 1 1986

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Talmadge, J. E., Lenz, B. F., Klabansky, R., Riggs, C., Guo, S., Simon, R., Oldham, R. K., & Fidler, I. J. (1986). Therapy of Autochthonous Skin Cancers in Mice with Intravenously Injected Liposomes Containing Muramyltripeptide1. Cancer Research, 46(3), 1160-1163.