TY - JOUR
T1 - Third ventricular injection of hypertonic NaCl
T2 - effect of renal denervation on natriuresis
AU - Zucker, I. H.
AU - Levine, N.
AU - Kaley, G.
PY - 1974
Y1 - 1974
N2 - The natriuretic response to administration of various hypertonic solutions into the third cerebral ventricle of anesthetized dogs was investigated. Injection or infusion of hypertonic (0.85 M) NaCl into the third ventricle induced a moderate and transient natriuresis as well as an increase in the percent filtered load of Na+ excreted. There was an acute elevation of 10-20 mm Hg in mean arterial blood pressure following injection of hypertonic NaCl into the third ventricle. Following unilateral renal denervation, injection of hypertonic NaCl resulted in similar increases in sodium excretion and in the percent filtered load of Na+ excreted in both innervated and denervated kidneys. Isotonic NaCl, hypertonic choline chloride, and hypertonic glucose were without effect, indicating that the natriuresis was a specific response to the increased concentration of Na+ in cerebrospinal fluid.
AB - The natriuretic response to administration of various hypertonic solutions into the third cerebral ventricle of anesthetized dogs was investigated. Injection or infusion of hypertonic (0.85 M) NaCl into the third ventricle induced a moderate and transient natriuresis as well as an increase in the percent filtered load of Na+ excreted. There was an acute elevation of 10-20 mm Hg in mean arterial blood pressure following injection of hypertonic NaCl into the third ventricle. Following unilateral renal denervation, injection of hypertonic NaCl resulted in similar increases in sodium excretion and in the percent filtered load of Na+ excreted in both innervated and denervated kidneys. Isotonic NaCl, hypertonic choline chloride, and hypertonic glucose were without effect, indicating that the natriuresis was a specific response to the increased concentration of Na+ in cerebrospinal fluid.
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U2 - 10.1152/ajplegacy.1974.227.1.35
DO - 10.1152/ajplegacy.1974.227.1.35
M3 - Article
C2 - 4407884
AN - SCOPUS:0016291315
VL - 227
SP - 35
EP - 41
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
SN - 0363-6127
IS - 1
ER -