Three-dimensional nanofiber scaffolds with arrayed holes for engineering skin tissue constructs

Lina Fu, Jingwei Xie, Mark A. Carlson, Debra A. Reilly

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Three-dimensional (3D) scaffolds composed of poly(ϵ-caprolactone) and gelatin nanofibers were fabricated by a combination of electrospinning and modified gas-foaming. Arrayed holes throughout the scaffold were created using a punch under cryo conditions. The crosslinking with glutaraldehyde vapor improved the water stability of the scaffolds. Cell spheroids of green fluorescent protein-labeled human dermal fibroblasts were prepared and seeded into the holes. It was found that the fibroblasts adhered well on the surface of nanofibers and migrated into the scaffolds due to the porous structures. The 3D nanofiber scaffolds may hold great potential for engineering tissue constructs for various applications.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalMRS Communications
Issue number3
StatePublished - Sep 1 2017

ASJC Scopus subject areas

  • General Materials Science


Dive into the research topics of 'Three-dimensional nanofiber scaffolds with arrayed holes for engineering skin tissue constructs'. Together they form a unique fingerprint.

Cite this