Three-dimensional structures of DNA-bound transcriptional regulators.

Tripti Shrivastava, Tahir H. Tahirov

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Our understanding of the detailed mechanisms of specific promoter/enhancer DNA-binding site recognition by transcriptional regulatory factors is primarily based on three-dimensional structural studies using the methods of X-ray crystallography and NMR. Vast amount of accumulated experimental data have revealed the basic principles of protein-DNA complex formation paving the way for better modeling and prediction of DNA-binding properties of transcription factors. In this review, our intent is to provide a general overview of the three-dimensional structures of DNA-bound transcriptional regulators starting from the basic principles of specific DNA recognition and ending with high-order multiprotein-DNA complexes.

Original languageEnglish (US)
Pages (from-to)43-55
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume674
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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