TY - JOUR
T1 - Thresholds for Interface Haze Formation After Thin-Flap Femtosecond Laser In Situ Keratomileusis for Myopia
AU - Rocha, Karolinne Maia
AU - Kagan, Roman
AU - Smith, Scott D.
AU - Krueger, Ronald R.
N1 - Funding Information:
This study was supported by an unrestricted grant from the Research to Prevent Blindness, New York, New York. Dr Krueger is a consultant for Alcon, which makes the excimer laser used in this study. Involved in design and conduct of study (K.M.R., R.R.K.); data collection (K.M.R., R.K.); management and interpretation of data (K.M.R., R.R.K.); data analysis (K.M.R., S.D.S.); manuscript preparation (R.K., K.M.R.), and manuscript review and approval (K.M.R., R.R.K., S.D.S., R.K.). The Institutional Review Board at Cleveland Clinic was contacted and approved the retrospective analysis of this data. This study followed the tenets of the Declaration of Helsinki.
PY - 2009/6
Y1 - 2009/6
N2 - Purpose: To evaluate the risk factors for interface haze formation after thin-flap femtosecond laser - laser in situ keratomileusis (LASIK). Design: Prospective case series. Methods: One hundred and ninety-nine consecutive eyes that underwent femtosecond laser LASIK with a LADAR 4000 excimer laser (Alcon Laboratories, Fort Worth, Texas, USA), were analyzed from January 1 to April 30, 2008. Treated eyes were divided into 2 groups according to desired flap thickness: 90 μm (106 eyes), and 100 to 110 μm (93 eyes). Cycloplegic refraction, spherical equivalent (SE), uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), depth of ablation, central corneal thickness, flap thickness (optical coherence tomography), Scheimpflug images (Pentacam; Oculus Inc, Lynnwood, Washington, USA), and light scattering were assessed in all eyes that developed haze postoperatively. Results: Haze was observed in 32 eyes treated for moderate to high myopia (SE -6.23 ± 1.67 diopters and depth of ablation 94.6 ± 22.9μm) at 3 months postoperatively. Ultra-thin IntraLASIK flaps (≤90 μm) and younger age were strongly associated with risk of postoperative haze (P = .003 and P = .01, respectively). SE, depth of ablation, and self-reported history of dry eyes were not independently associated with an increased risk of corneal haze. Patients who developed any degree of haze had significantly higher logarithmic value of scatter (log S) values (mean difference =0.24 units, P < .0005) compared with those who did not develop haze. The mean postoperative BSCVA was good in all eyes with haze (logarithm of the minimal angle of resolution 0.05 ± 0.04). Conclusion: Interface haze is associated with an ultra-thin femtosecond laser flap setting of 90 μm and younger age among eyes following LASIK for myopia.
AB - Purpose: To evaluate the risk factors for interface haze formation after thin-flap femtosecond laser - laser in situ keratomileusis (LASIK). Design: Prospective case series. Methods: One hundred and ninety-nine consecutive eyes that underwent femtosecond laser LASIK with a LADAR 4000 excimer laser (Alcon Laboratories, Fort Worth, Texas, USA), were analyzed from January 1 to April 30, 2008. Treated eyes were divided into 2 groups according to desired flap thickness: 90 μm (106 eyes), and 100 to 110 μm (93 eyes). Cycloplegic refraction, spherical equivalent (SE), uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), depth of ablation, central corneal thickness, flap thickness (optical coherence tomography), Scheimpflug images (Pentacam; Oculus Inc, Lynnwood, Washington, USA), and light scattering were assessed in all eyes that developed haze postoperatively. Results: Haze was observed in 32 eyes treated for moderate to high myopia (SE -6.23 ± 1.67 diopters and depth of ablation 94.6 ± 22.9μm) at 3 months postoperatively. Ultra-thin IntraLASIK flaps (≤90 μm) and younger age were strongly associated with risk of postoperative haze (P = .003 and P = .01, respectively). SE, depth of ablation, and self-reported history of dry eyes were not independently associated with an increased risk of corneal haze. Patients who developed any degree of haze had significantly higher logarithmic value of scatter (log S) values (mean difference =0.24 units, P < .0005) compared with those who did not develop haze. The mean postoperative BSCVA was good in all eyes with haze (logarithm of the minimal angle of resolution 0.05 ± 0.04). Conclusion: Interface haze is associated with an ultra-thin femtosecond laser flap setting of 90 μm and younger age among eyes following LASIK for myopia.
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U2 - 10.1016/j.ajo.2009.01.010
DO - 10.1016/j.ajo.2009.01.010
M3 - Article
C2 - 19327748
AN - SCOPUS:67349130192
SN - 0002-9394
VL - 147
SP - 966-972.e1
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -