Thrombolytic therapy for acute extra-cranial artery dissection report of two cases

O. O. Zaidat, J. Fernandes Filho, M. Americo, G. Suarez, J. I. Singh

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Extra-cranial arterial dissection accounts for 10% of strokes in young people. Information on safety of thrombolytic administration in this group is limited. The literature, however, does not favor use of thrombolytics for myocardial ischemia when peripheral arterial dissection coexists. Based on the clinical and radiological features, two patients who presented with acute stroke secondary to arterial dissection were considered for thrombolysis. One of them received intra-venous recombinant tissue plasminogen activator (rtPA), and the other patient received intra-arterial rtPA. There were no post thrombolysis complications. This report supports feasibility of administering thrombolytics in acute ischemic strokes resulting from extra-cranial arterial dissection. Future larger studies are necessary to determine the efficacy, safety and long-term outcome in this patient population.

Original languageEnglish (US)
Pages (from-to)936-938
Number of pages3
JournalArquivos de Neuro-Psiquiatria
Issue number4
StatePublished - 2001
Externally publishedYes


  • Dissection
  • Internal carotid artery.
  • Stroke
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

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