Thyroid dependent maturation of β-adrenergic receptors in the rat lung

Jeffrey A. Whitsett, C. Darovec-Beckerman, Karen Adams, Jennifer Pollinger, Howard Needelman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

β-Adrenergic receptors were identified in membranes of fetal and postnatal rat lung with (-)-[3H]dihydroalprenolol, [3H]DHA. β-Receptor number (Bmax) increased 11-fold from day 18 of gestation to adult levels by day 28 of postnatal life. The increase of β-adrenergic receptors occurring between postnatal days 15 and 28 was dependent on thyroxine (T4) in propylthiouracil treated pups. β-Adrenergic receptors on day 28 were identical in euthyroid (PTU + T4) as compared to normal control pups (489±31 and 491±30 femtomoles·mg-1) however receptors were markedly reduced in 28 day hypothyroid pups (PTU alone), Bmax = 294±21.5, m±S.E. p<0.01. Treatment of the hypothyroid pups with T4 for three days on postnatal day 25 increased β-adrenergic receptors approximately two-fold by day 28. This thyroid hormone dependent increase in lung β-adrenergic receptors occurs between postnatal days 15 and 28 coincident with the known increase in thyroid gland activity in the rat pup.

Original languageEnglish (US)
Pages (from-to)913-917
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume97
Issue number3
DOIs
StatePublished - Dec 16 1980

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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