Abstract
Introduction: Otological symptoms contribute to the disability of established Parkinson's disease (PD). We sought to evaluate whether prodromal onset may affect PD progression. Methods: A retrospective cohort design was used to compare time to advanced disease, defined as a Hoehn & Yahr stage ≥3 in consecutive PD patients with history of auditory and/or vestibular symptoms appearing before versus after PD onset. Time from PD onset to H&Y ≥ 3 was determined using Cox proportional hazards, with adjusted results summarized as hazards ratio (HR). Results: After adjusting for age at PD onset, there was a lower risk of progression to advanced disease in patients with prodromal otological symptoms compared to those with otological symptoms after PD onset (HR = 0.34; 95%CI: 0.15–0.75, p = 0.008). This association remained significant after adjusting for age at PD onset and MDS-UPDRS III (HR = 0.25; 95% CI: 0.10–0.63, p = 0.003) and propensity score-adjusted analysis (HR = 0.46; 95% CI: 0.24–0.91, p = 0.025). Conclusion: Prodromal otological symptoms might be associated with a reduced risk of motor progression in PD.
Original language | English (US) |
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Pages (from-to) | 23-26 |
Number of pages | 4 |
Journal | Parkinsonism and Related Disorders |
Volume | 90 |
DOIs | |
State | Published - Sep 2021 |
Keywords
- Hearing loss
- Meniere's disease
- Otology
- Parkinson's disease
- Vertigo
ASJC Scopus subject areas
- Neurology
- Geriatrics and Gerontology
- Clinical Neurology