TY - JOUR
T1 - Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA
AU - Jbilo, Omar
AU - Bartels, Cynthia F.
AU - Chatonnet, Arnaud
AU - Toutant, Jean Pierre
AU - Lockridge, Oksana
N1 - Funding Information:
Acknowledgements-This work was supported by U.S . Army Medical Research and Development Command Grant DAMD17-91-2-1003 and DAMD17-94J-4005 (to O.L.), American Cancer Society grants SIG-16A and IRG-165E, and National Cancer Institute Grant P30 CA 36727 to The Eppley Institute, and by a grant from the Minist6re de la Recherche et de la Technologic (MRT 91T0439) .
PY - 1994/11
Y1 - 1994/11
N2 - O. Jbilo, C. F. Bartels, A. Chatonnet, J.-P. Toutant and O. Lockridge. Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA. Toxicon 32, 1445-1457, 1994.-Cholinesterase inhibitors occur naturally in the calabar bean (eserine), green potatoes (solanine), insect-resistant crab apples, the coca plant (cocaine) and snake venom (fasciculin). There are also synthetic cholinesterase inhibitors, for example man-made insecticides. These inhibitors inactivate acetylcholinesterase and butyrylcholinesterase as well as other targets. From a study of the tissue distribution of acetylcholinesterase and butyrylcholinesterase mRNA by Northern blot analysis, we have found the highest levels of butyrylcholinesterase mRNA in the liver and lungs, tissues known as the principal detoxication sites of the human body. These results indicate that butyrylcholinesterase may be a first line of defense against poisons that are eaten or inhaled.
AB - O. Jbilo, C. F. Bartels, A. Chatonnet, J.-P. Toutant and O. Lockridge. Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA. Toxicon 32, 1445-1457, 1994.-Cholinesterase inhibitors occur naturally in the calabar bean (eserine), green potatoes (solanine), insect-resistant crab apples, the coca plant (cocaine) and snake venom (fasciculin). There are also synthetic cholinesterase inhibitors, for example man-made insecticides. These inhibitors inactivate acetylcholinesterase and butyrylcholinesterase as well as other targets. From a study of the tissue distribution of acetylcholinesterase and butyrylcholinesterase mRNA by Northern blot analysis, we have found the highest levels of butyrylcholinesterase mRNA in the liver and lungs, tissues known as the principal detoxication sites of the human body. These results indicate that butyrylcholinesterase may be a first line of defense against poisons that are eaten or inhaled.
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U2 - 10.1016/0041-0101(94)90416-2
DO - 10.1016/0041-0101(94)90416-2
M3 - Article
C2 - 7886701
AN - SCOPUS:0028127008
SN - 0041-0101
VL - 32
SP - 1445
EP - 1457
JO - Toxicon
JF - Toxicon
IS - 11
ER -