Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA

Omar Jbilo, Cynthia F. Bartels, Arnaud Chatonnet, Jean Pierre Toutant, Oksana Lockridge

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

O. Jbilo, C. F. Bartels, A. Chatonnet, J.-P. Toutant and O. Lockridge. Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA. Toxicon 32, 1445-1457, 1994.-Cholinesterase inhibitors occur naturally in the calabar bean (eserine), green potatoes (solanine), insect-resistant crab apples, the coca plant (cocaine) and snake venom (fasciculin). There are also synthetic cholinesterase inhibitors, for example man-made insecticides. These inhibitors inactivate acetylcholinesterase and butyrylcholinesterase as well as other targets. From a study of the tissue distribution of acetylcholinesterase and butyrylcholinesterase mRNA by Northern blot analysis, we have found the highest levels of butyrylcholinesterase mRNA in the liver and lungs, tissues known as the principal detoxication sites of the human body. These results indicate that butyrylcholinesterase may be a first line of defense against poisons that are eaten or inhaled.

Original languageEnglish (US)
Pages (from-to)1445-1457
Number of pages13
JournalToxicon
Volume32
Issue number11
DOIs
StatePublished - Nov 1994

ASJC Scopus subject areas

  • Toxicology

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