Tissue factor (coagulation factor III) is present in placental microvilli and cofractionates with microvilli membrane proteins

Steven D. Carson, Catherine A. Ramsey

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We have demonstrated that tissue factor is present in preparations of placental microvilli. The similarity of the procoagulant activities of microvilli and placental homogenates indicate that tissue factor is neither deficient nor enriched in microvilli relative to the bulk of placental tissue. On the basis of solubility in Triton X-100 and ammonium sulphate, and its affinity for phenyl-Sepharose, microvilli tissue factor is indistinguishable from that in whole placental homogenates.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalPlacenta
Volume6
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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