Tissue factor gene localized to human chromosome 1 (1pter→1p21)

Steven D. Carson; W. Michael Henry; Thomas B. Shows

doi:10.1126/science.4023720

Tissue factor gene localized to human chromosome 1 (1pter→1p21)

Steven D. Carson, W. Michael Henry, Thomas B. Shows

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26 Scopus citations

Abstract

Tissue factor (tissue thromboplastin, coagulation factor III), a protein component of cell membranes, is an essential cofactor for factor VII-dependent initiation of blood coagulation. Since no tissue factor-deficient condition has been described, it is one of only a few proteins of the coagulation system for which the pattern of inheritance has not been ascertained. Because of the species-specificity of tissue factor activity and the availability of a very sensitive chromogenic assay, it was possible in the present study to use somatic cell hybrids to assign the chromosomal location of the tissue factor structural gene (F3) to human chromosome 1 (1pter→1p21).

Original language	English (US)
Pages (from-to)	991-993
Number of pages	3
Journal	Science
Volume	229
Issue number	4717
DOIs	https://doi.org/10.1126/science.4023720
State	Published - 1985
Externally published	Yes

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title = "Tissue factor gene localized to human chromosome 1 (1pter→1p21)",

abstract = "Tissue factor (tissue thromboplastin, coagulation factor III), a protein component of cell membranes, is an essential cofactor for factor VII-dependent initiation of blood coagulation. Since no tissue factor-deficient condition has been described, it is one of only a few proteins of the coagulation system for which the pattern of inheritance has not been ascertained. Because of the species-specificity of tissue factor activity and the availability of a very sensitive chromogenic assay, it was possible in the present study to use somatic cell hybrids to assign the chromosomal location of the tissue factor structural gene (F3) to human chromosome 1 (1pter→1p21).",

author = "Carson, {Steven D.} and Henry, {W. Michael} and Shows, {Thomas B.}",

year = "1985",

doi = "10.1126/science.4023720",

language = "English (US)",

volume = "229",

pages = "991--993",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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T1 - Tissue factor gene localized to human chromosome 1 (1pter→1p21)

AU - Carson, Steven D.

AU - Henry, W. Michael

AU - Shows, Thomas B.

PY - 1985

Y1 - 1985

N2 - Tissue factor (tissue thromboplastin, coagulation factor III), a protein component of cell membranes, is an essential cofactor for factor VII-dependent initiation of blood coagulation. Since no tissue factor-deficient condition has been described, it is one of only a few proteins of the coagulation system for which the pattern of inheritance has not been ascertained. Because of the species-specificity of tissue factor activity and the availability of a very sensitive chromogenic assay, it was possible in the present study to use somatic cell hybrids to assign the chromosomal location of the tissue factor structural gene (F3) to human chromosome 1 (1pter→1p21).

AB - Tissue factor (tissue thromboplastin, coagulation factor III), a protein component of cell membranes, is an essential cofactor for factor VII-dependent initiation of blood coagulation. Since no tissue factor-deficient condition has been described, it is one of only a few proteins of the coagulation system for which the pattern of inheritance has not been ascertained. Because of the species-specificity of tissue factor activity and the availability of a very sensitive chromogenic assay, it was possible in the present study to use somatic cell hybrids to assign the chromosomal location of the tissue factor structural gene (F3) to human chromosome 1 (1pter→1p21).

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SP - 991

EP - 993

JO - Science

JF - Science

IS - 4717

ER -

Tissue factor gene localized to human chromosome 1 (1pter→1p21)

Abstract

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