Tissue factor in chronic villitis of unestablished etiology

Carlos A. Labarrere, Steven D. Carson, W. Page Faulk

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We have previously reported the presence in normal human placentae of coagulation, macrophages and helper T lymphocytes in inflammatory foci known as villitis of unestablished etiology. In order to investigate the link between coagulation and immunity, we have studied fetal stem vessel endothelium for tissue factor, which is made available by cytokines and activates coagulation via the extrinsic pathway. We found that fetal stem vessel endothelial cells of normal chorionic villi did not react with antibody to tissue factor. Normal placentae contain small numbers of villitis areas and endothelium in these areas was reactive with antibody to tissue factor. Endothelial tissue factor reactivity was more prominent in placentae from secondary recurrent spontaneous aborters and these placentae have greatly increased numbers of villitis areas. The tissue factor availability on fetal stem vessel endothelium may result from immunologically mediated cytokine release. The net effect of these reactions is the presence of lymphocytes, macrophages, coagulation, necrosis and vasculitis in villitis.

Original languageEnglish (US)
Pages (from-to)225-235
Number of pages11
JournalJournal of Reproductive Immunology
Issue number3
StatePublished - Apr 1991


  • chronic villitis
  • coagulation
  • endothelial cells
  • placentae
  • tissue factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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