TY - JOUR
T1 - Titanium implant with nanostructured zirconia surface promotes maturation of peri-implant bone in osseointegration
AU - Dusad, Anand
AU - Chakkalakal, Dennis A.
AU - Namavar, Fereydoon
AU - Haider, Hani
AU - Hanisch, Brock
AU - Duryee, Michael J.
AU - Diaz, April
AU - Rensch, Adam
AU - Zhang, Yijia
AU - Hess, Ryan
AU - Thiele, Geoffrey Milton
AU - Fehringer, Edward V.
N1 - Funding Information:
This study was supported by the Nebraska Arthritis Outcomes Research Center NAORC and The Department of Internal Medicine, University of Nebraska Medical Center.
PY - 2013/5
Y1 - 2013/5
N2 - The goal of the experiment outlined in this article is to improve upon noncemented methods of arthroplasty for clinical application in elderly patients. This was done by determining whether titanium implants with a novel nanostructured zirconia surface, which was created by ion beam-assisted deposition, would prevent impaired osseointegration of intramedullary implants in 1-year-old rats receiving a protein-deficient diet. Specifically, we asked whether the implant with the nanostructured zirconia surface would increase expression of markers of bone maturation within the remodeling of peri-implant woven bone. The control implants, which were made of commercially pure titanium, had a polished surface ex vivo but are known to acquire a microstructured titania surface in vivo. Ten 1-year-old rats received experimental implant (group A) and 10 had control (group B) implants. Ten 3-month-old rats received normal protein diet and the control implant (group C). Animals were euthanized 8 weeks after implantation, and transverse sections of femurimplant samples were used for histology, micro-computed tomography and immunohistochemical evaluations. In group B, the expression of a2b1 and a5b1 integrins, which are known to mediate osteoblast adhesion, glycosaminoglycans, heparan sulfate and chondroitin sulfate, was less than half of that in group C. Important to this study, the zirconia surface used in group A prevented these deficiencies. Therefore, these results indicate that nanostructured zirconia surface created on clinical implants by ion beam-assisted deposition may prevent impaired osseointegration in elderly patients by promoting quicker maturation of peri-implant woven bone.
AB - The goal of the experiment outlined in this article is to improve upon noncemented methods of arthroplasty for clinical application in elderly patients. This was done by determining whether titanium implants with a novel nanostructured zirconia surface, which was created by ion beam-assisted deposition, would prevent impaired osseointegration of intramedullary implants in 1-year-old rats receiving a protein-deficient diet. Specifically, we asked whether the implant with the nanostructured zirconia surface would increase expression of markers of bone maturation within the remodeling of peri-implant woven bone. The control implants, which were made of commercially pure titanium, had a polished surface ex vivo but are known to acquire a microstructured titania surface in vivo. Ten 1-year-old rats received experimental implant (group A) and 10 had control (group B) implants. Ten 3-month-old rats received normal protein diet and the control implant (group C). Animals were euthanized 8 weeks after implantation, and transverse sections of femurimplant samples were used for histology, micro-computed tomography and immunohistochemical evaluations. In group B, the expression of a2b1 and a5b1 integrins, which are known to mediate osteoblast adhesion, glycosaminoglycans, heparan sulfate and chondroitin sulfate, was less than half of that in group C. Important to this study, the zirconia surface used in group A prevented these deficiencies. Therefore, these results indicate that nanostructured zirconia surface created on clinical implants by ion beam-assisted deposition may prevent impaired osseointegration in elderly patients by promoting quicker maturation of peri-implant woven bone.
KW - Bone
KW - Micro-computed tomography
KW - Osseointegration
KW - Rat implant model
KW - Titanium implant
KW - Zirconia oxide
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U2 - 10.1177/0954411913479300
DO - 10.1177/0954411913479300
M3 - Article
C2 - 23637261
AN - SCOPUS:84879196400
SN - 0954-4119
VL - 227
SP - 510
EP - 522
JO - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
JF - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
IS - 5
ER -