Abstract
Toll-like receptors (TLRs) are a family of pattern-recognition receptors expressed on cells of the innate immune system that allow for the recognition of conserved structural motifs on a wide array of pathogens, referred to as pathogen-associated molecular patterns, as well as some endogenous molecules. The recent emergence of studies examining TLRs in the central nervous system (CNS) indicates that these receptors not only play a role in innate immunity in response to infectious diseases but may also participate in CNS autoimmunity, neurodegeneration, and tissue injury. This review summarizes the experimental evidence demonstrating a role for TLRs in the context of CNS inflammation in both infectious and noninfectious conditions.
Original language | English (US) |
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Pages (from-to) | 711-730 |
Number of pages | 20 |
Journal | Journal of Neuroscience Research |
Volume | 83 |
Issue number | 5 |
DOIs | |
State | Published - Apr 2006 |
Externally published | Yes |
Keywords
- Central nervous system
- Pathogen-associated molecular pattern (PAMP)
- Pattern recognition receptor (PRR)
- Toll-like receptor (TLR)
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience