Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer

Kelly C. Landeen, William C. Spanos, Laurie Gromer

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Topical superoxide dismutase (SOD) has been shown to decrease postradiation fibrosis in some cancers but has not demonstrated an effect in patients with head and neck cancer. The purpose of this study was to determine if topical SOD is an effective treatment for postradiation neck fibrosis. Methods: This was a randomized prospective blinded clinical study of topical SOD versus placebo for the treatment of neck fibrosis. Measures of fibrosis grade and quality of life were obtained at baseline and after 3 months of treatment. Results: Improvement in fibrosis score was comparable between the 2 study arms at 3 months. Conclusion: Both study groups showed improvement but the differences between groups was not statistically significant. Topical SOD likely has limited benefit for posttreatment neck fibrosis but this study confirms other published evidence of benefit from active physical therapy of posttreatment fibrosis in patients with head and neck cancer.

Original languageEnglish (US)
Pages (from-to)1400-1405
Number of pages6
JournalHead and Neck
Volume40
Issue number7
DOIs
StatePublished - Jul 2018

Keywords

  • fibrosis
  • head and neck cancer
  • quality of life
  • radiation
  • superoxide dismutase

ASJC Scopus subject areas

  • Otorhinolaryngology

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