Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia

N. K.C. Ramsay, T. Kim, M. E. Nesbit, W. Krivit, P. F. Coccia, S. H. Levitt, W. G. Woods, J. H. Kersey

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibling following this preparative regimen. There were no episodes of graft rejection, and only one patient developed graft-versus-host disease. Of the 9 patients, 7 (78%) are surviving with a median follow-up of 400 days. The excellent results of this pretransplant combination of total lymphoid irradiation and cyclophosphamide warrants application of this regimen to a larger series of patients.

Original languageEnglish (US)
Pages (from-to)344-346
Number of pages3
JournalBlood
Volume55
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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