Total synthesis of (±)-Marinopyrrole a and its library as potential antibiotic and anticancer agents

Chunwei Cheng; Lili Pan; Yi Chen; Hao Song; Yong Qin; Rongshi Li

doi:10.1021/cc100052j

Total synthesis of (±)-Marinopyrrole a and its library as potential antibiotic and anticancer agents

Chunwei Cheng, Lili Pan, Yi Chen, Hao Song, Yong Qin, Rongshi Li

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The first total synthesis of marine natural product, (±)- marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.

Original language	English (US)
Pages (from-to)	541-547
Number of pages	7
Journal	Journal of Combinatorial Chemistry
Volume	12
Issue number	4
DOIs	https://doi.org/10.1021/cc100052j
State	Published - Jul 12 2010
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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10.1021/cc100052j

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abstract = "The first total synthesis of marine natural product, (±)- marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.",

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AU - Cheng, Chunwei

AU - Pan, Lili

AU - Chen, Yi

AU - Song, Hao

AU - Qin, Yong

AU - Li, Rongshi

PY - 2010/7/12

Y1 - 2010/7/12

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Total synthesis of (±)-Marinopyrrole a and its library as potential antibiotic and anticancer agents

Abstract

ASJC Scopus subject areas

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