Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: Randomized controlled trials overestimate treatment response and effectiveness

F. Wolfe, K. Michaud

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The results and outcomes of randomized clinical trials of leflunomide and anti-TNF therapy are much better than are seen in rheumatoid arthritis patients in the community. This appears to be an effect of the clinical trial system. The consequence of deriving effectiveness estimates from clinical trials is to overestimate the effectiveness and thereby the cost-effectiveness of rheumatoid arthritis treatments.

Original languageEnglish (US)
Pages (from-to)iv18-iv22
JournalRheumatology
Volume44
Issue numberSUPPL. 4
DOIs
StatePublished - Dec 2005
Externally publishedYes

Keywords

  • Bias
  • Observational studies
  • Outcome
  • Randomized controlled trials
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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