Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: Randomized controlled trials overestimate treatment response and effectiveness

F. Wolfe; K. Michaud

doi:10.1093/rheumatology/kei056

Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: Randomized controlled trials overestimate treatment response and effectiveness

F. Wolfe, K. Michaud

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The results and outcomes of randomized clinical trials of leflunomide and anti-TNF therapy are much better than are seen in rheumatoid arthritis patients in the community. This appears to be an effect of the clinical trial system. The consequence of deriving effectiveness estimates from clinical trials is to overestimate the effectiveness and thereby the cost-effectiveness of rheumatoid arthritis treatments.

Original language	English (US)
Pages (from-to)	iv18-iv22
Journal	Rheumatology
Volume	44
Issue number	SUPPL. 4
DOIs	https://doi.org/10.1093/rheumatology/kei056
State	Published - Dec 2005
Externally published	Yes

Keywords

Bias
Observational studies
Outcome
Randomized controlled trials
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology
Pharmacology (medical)

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10.1093/rheumatology/kei056

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abstract = "The results and outcomes of randomized clinical trials of leflunomide and anti-TNF therapy are much better than are seen in rheumatoid arthritis patients in the community. This appears to be an effect of the clinical trial system. The consequence of deriving effectiveness estimates from clinical trials is to overestimate the effectiveness and thereby the cost-effectiveness of rheumatoid arthritis treatments.",

keywords = "Bias, Observational studies, Outcome, Randomized controlled trials, Rheumatoid arthritis",

author = "F. Wolfe and K. Michaud",

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AU - Michaud, K.

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N2 - The results and outcomes of randomized clinical trials of leflunomide and anti-TNF therapy are much better than are seen in rheumatoid arthritis patients in the community. This appears to be an effect of the clinical trial system. The consequence of deriving effectiveness estimates from clinical trials is to overestimate the effectiveness and thereby the cost-effectiveness of rheumatoid arthritis treatments.

AB - The results and outcomes of randomized clinical trials of leflunomide and anti-TNF therapy are much better than are seen in rheumatoid arthritis patients in the community. This appears to be an effect of the clinical trial system. The consequence of deriving effectiveness estimates from clinical trials is to overestimate the effectiveness and thereby the cost-effectiveness of rheumatoid arthritis treatments.

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KW - Observational studies

KW - Outcome

KW - Randomized controlled trials

KW - Rheumatoid arthritis

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Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: Randomized controlled trials overestimate treatment response and effectiveness

Abstract

Keywords

ASJC Scopus subject areas

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