TOXICOLOGY AND HISTOPATHOLOGY OF THE HEAT‐STABLE ENTEROTOXIN OF YERSINIA ENTEROCOLITICA IN INFANT AND ADULT MICE

ALISON R. BEHLING, JOHN T. BEERY, STEVE L. TAYLOR

Research output: Contribution to journalArticlepeer-review

Abstract

Yersinia enterocolitica heat‐stable enterotoxin (YST) was partially purified by ion exchange, gel filtration and Fast Protein Liquid chromatography. Infant mice given YST orally (p.o.) exhibited diarrhea 4 h after administration; a few infants died by 6.5 h. Pups dosed intraperitoneally (i.p.) and adults dosed p.o., i.p. and intravenously showed no symptoms during the 7 days of observations. Tissues of adult mice orally challenged with YST showed no pathological changes by light microscopy. Livers of infant mice orally dosed with YST showed evidence of severe glycogen depletion. The intestinal tracts of YST‐dosed (p.o.) infant mice exhibited severe pathological changes including: epithelial cell and villous tip necrosis, villous edema, and capillary and lacteal engorgement. Kidneys of YST‐dosed (p.o.) infant mice exhibited devacuolization of the proximal convoluted tubule cells which indicates metabolic inactivity and a probable decrease in the resorption of glomerular filtrate (protein, carbohydrate, electrolytes and water).

Original languageEnglish (US)
Pages (from-to)119-133
Number of pages15
JournalJournal of Food Safety
Volume9
Issue number2
DOIs
StatePublished - Jul 1988
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Food Science
  • Microbiology

Fingerprint Dive into the research topics of 'TOXICOLOGY AND HISTOPATHOLOGY OF THE HEAT‐STABLE ENTEROTOXIN OF YERSINIA ENTEROCOLITICA IN INFANT AND ADULT MICE'. Together they form a unique fingerprint.

Cite this