Transcranial threshold of inertial cavitation induced by diagnostic ultrasound and microbubbles

Jinjin Liu, Shunji Gao, Thomas Porter, Carr Everbach, William Shi, Francois Vignon, Jeffry Powers, John Lof, Joseph Turner, Feng Xie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Inertial cavitation may cause hazardous bioeffects during microbubble mediated sonothrombolysis. The purpose of this study was to investigate the influence of ultrasound pulse length and temporal bone on inertial cavitation thresholds within the brain utilizing transtemporal imaging transducers. A pig temporal bone overlaid with muscle tissue was placed over silastic tubing containing a dilute microbubble infusion (1% Definity) within Phosphate Buffered Saline at 37°C. A 1.6 MHz Philips iE33 two-dimensional probe (S5-1) imaged at incremental peak negative pressures. Broadband noise signals were recorded to characterize inertial cavitation using two 20 MHz passive cavitation detectors. Peak-negative-pressure thresholds of inertial cavitation were approximately 263 kPa and 235 kPa with and without bone for 5 microsecond pulse length, and 217 kPa and 215 kPa with and without bone for 20 microsecond pulse length, respectively. The threshold of inertial cavitation is associated with ultrasound pulse length and temporal bone.

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Pages221-226
Number of pages6
DOIs
StatePublished - 2012
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
Volume1481
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference11th International Symposium on Therapeutic Ultrasound, ISTU 2011
CountryUnited States
CityNew York, NY
Period4/11/114/13/11

Keywords

  • Inertial cavitation
  • Microbubbles
  • Thrombolysis
  • Transcranial diagnostic ultrasound

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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