Transcription factor expression during pancreatic islet regeneration

Marcie R. Kritzik, Troy Krahl, Augusta Good, Michelle Krakowski, Luc St.-Onge, Peter Gruss, Christopher Wright, Nora Sarvetnick

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Recent studies by a number of laboratories have identified transcription factors that are involved in pancreatic development. Indeed, marked abnormalities in pancreatic development result from deficiencies in these molecules, which include, among others, PDX-1, islet-1 (Isl-1), and Pax-6. These studies have prompted us to evaluate the expression of Isl-1 and Pax-6 in the pancreas of the interferon-gamma (IFNγ) transgenic mouse, which exhibits new islet growth and expansion of ducts throughout the life of the animal. We have previously demonstrated that PDX-1 is strikingly expressed in the ducts of the IFNγ transgenic mouse. This latter observation compelled us to examine expression of hepatocyte nuclear factor-3beta (HNF3β), which mediates PDX-1 gene transcription, in the IFNγ transgenic pancreas as well. As a result of these studies, we now demonstrate marked expression of these transcription factors in the pancreatic ducts of IFNγ transgenic mice. These data suggest a role for these transcription factors during pancreatic regeneration in the IFNγ transgenic mouse. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume164
Issue number1-2
DOIs
StatePublished - Jun 20 2000

Keywords

  • Hepatocyte nuclear factor-3beta
  • Islet-1
  • Pancreas
  • Pax-6
  • Regeneration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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