Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines

Yutaka Tagaya, Yoshihisa Taniguchi, Mayumi Naramura, Masafumi Okada, Noboru Suzuki, Hiroshi Kanamori, Toshio Nikaido, Tasuku Honjo, Junji Yodoi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In HTLV-I transformed T-cell lines established from the patients with adult T-cell leukemia (ATL), there is a constitutive activation of the normal IL-2 receptor (IL-2-R) gene. These cell lines continuously produce an ATL-derived factor (ADF), an IL-2-R inducing factor without IL-2 activity. ADF enhances the expression of the IL-2-R through the augmentation of the IL-2-R mRNA in the HTLV-I(+) T-cell line (ED) as well as the NK cell line cells (YT). In YT cells, the transcriptional initiation of the promoter of the IL-2-R gene was enhanced by ADF but not by IL-2. Production of ADF by HTLV-I(+) T-cell lines may be involved in the abnormal expression of IL-2-Rs on these cells.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalImmunology Letters
Volume15
Issue number3
DOIs
StatePublished - Jul 1987

Keywords

  • ADF
  • ATL
  • IL-2 receptor
  • Interleukin-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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