Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7

T. J. Stivrins, R. B. Davis, W. Sanger, J. Fritz, D. T. Purtilo

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Abstract

Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalBlood
Volume64
Issue number1
Publication statusPublished - Aug 30 1984

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Stivrins, T. J., Davis, R. B., Sanger, W., Fritz, J., & Purtilo, D. T. (1984). Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. Blood, 64(1), 173-176.