Transformative impact of proteomics on cardiovascular health and disease: A scientific statement from the American Heart Association

Merry L. Lindsey, Manuel Mayr, Aldrin V. Gomes, Christian Delles, D. Kent Arrell, Anne M. Murphy, Richard A. Lange, Catherine E. Costello, Yu Fang Jin, Daniel T. Laskowitz, Flora Sam, Andre Terzic, Jennifer Van Eyk, Pothur R. Srinivas

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

The year 2014 marked the 20th anniversary of the coining of the term proteomics. The purpose of this scientific statement is to summarize advances over this period that have catalyzed our capacity to address the experimental, translational, and clinical implications of proteomics as applied to cardiovascular health and disease and to evaluate the current status of the field. Key successes that have energized the field are delineated; opportunities for proteomics to drive basic science research, facilitate clinical translation, and establish diagnostic and therapeutic healthcare algorithms are discussed; and challenges that remain to be solved before proteomic technologies can be readily translated from scientific discoveries to meaningful advances in cardiovascular care are addressed. Proteomics is the result of disruptive technologies, namely, mass spectrometry and database searching, which drove protein analysis from 1 protein at a time to protein mixture analyses that enable large-scale analysis of proteins and facilitate paradigm shifts in biological concepts that address important clinical questions. Over the past 20 years, the field of proteomics has matured, yet it is still developing rapidly. The scope of this statement will extend beyond the reaches of a typical review article and offer guidance on the use of next-generation proteomics for future scientific discovery in the basic research laboratory and clinical settings.

Original languageEnglish (US)
Pages (from-to)852-872
Number of pages21
JournalCirculation
Volume132
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • AHA Scientific Statements
  • biomarkers
  • mass spectrometry
  • proteome
  • systems biology
  • translational research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Lindsey, M. L., Mayr, M., Gomes, A. V., Delles, C., Arrell, D. K., Murphy, A. M., Lange, R. A., Costello, C. E., Jin, Y. F., Laskowitz, D. T., Sam, F., Terzic, A., Van Eyk, J., & Srinivas, P. R. (2015). Transformative impact of proteomics on cardiovascular health and disease: A scientific statement from the American Heart Association. Circulation, 132(9), 852-872. https://doi.org/10.1161/CIR.0000000000000226