Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice

Myung Shik Lee; Stephen Sawyer; Marc Arnush; Troy Krahl; Matthias Von Herrath; Michael B.A. Oldstone; Nora Sarvetnick

Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice

Myung Shik Lee, Stephen Sawyer, Marc Arnush, Troy Krahl, Matthias Von Herrath, Michael B.A. Oldstone, Nora Sarvetnick

Research output: Contribution to journal › Article › peer-review

Abstract

Transgenic mice whose pancreata express transforming growth factor-β (TGF-β) directed by an insulin promoter (Ins-TGF-β mice) were used to assess the effect of local TGF-β1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-β1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-β1 mice). These results suggest that local TGF-β1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.

Original language	English (US)
Pages (from-to)	1112-1113
Number of pages	2
Journal	Transplantation
Volume	61
Issue number	7
State	Published - Apr 15 1996
Externally published	Yes

ASJC Scopus subject areas

Transplantation

Cite this

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title = "Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice",

abstract = "Transgenic mice whose pancreata express transforming growth factor-β (TGF-β) directed by an insulin promoter (Ins-TGF-β mice) were used to assess the effect of local TGF-β1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-β1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-β1 mice). These results suggest that local TGF-β1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.",

author = "Lee, {Myung Shik} and Stephen Sawyer and Marc Arnush and Troy Krahl and {Von Herrath}, Matthias and Oldstone, {Michael B.A.} and Nora Sarvetnick",

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AU - Lee, Myung Shik

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AU - Arnush, Marc

AU - Krahl, Troy

AU - Von Herrath, Matthias

AU - Oldstone, Michael B.A.

AU - Sarvetnick, Nora

PY - 1996/4/15

Y1 - 1996/4/15

N2 - Transgenic mice whose pancreata express transforming growth factor-β (TGF-β) directed by an insulin promoter (Ins-TGF-β mice) were used to assess the effect of local TGF-β1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-β1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-β1 mice). These results suggest that local TGF-β1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.

AB - Transgenic mice whose pancreata express transforming growth factor-β (TGF-β) directed by an insulin promoter (Ins-TGF-β mice) were used to assess the effect of local TGF-β1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-β1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-β1 mice). These results suggest that local TGF-β1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.

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Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice

Abstract

ASJC Scopus subject areas

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