Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice

Myung Shik Lee, Stephen Sawyer, Marc Arnush, Troy Krahl, Matthias Von Herrath, Michael B.A. Oldstone, Nora Sarvetnick

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21 Scopus citations

Abstract

Transgenic mice whose pancreata express transforming growth factor-β (TGF-β) directed by an insulin promoter (Ins-TGF-β mice) were used to assess the effect of local TGF-β1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-β1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-β1 mice). These results suggest that local TGF-β1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.

Original languageEnglish (US)
Pages (from-to)1112-1113
Number of pages2
JournalTransplantation
Volume61
Issue number7
StatePublished - Apr 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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    Lee, M. S., Sawyer, S., Arnush, M., Krahl, T., Von Herrath, M., Oldstone, M. B. A., & Sarvetnick, N. (1996). Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice. Transplantation, 61(7), 1112-1113.