Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA helicase

D. Wu-Scharf, B. R. Jeong, C. Zhang, H. Cerutti

Research output: Contribution to journalArticlepeer-review

223 Scopus citations

Abstract

The molecular mechanism(s) responsible for posttranscriptional gene silencing and RNA interference remain poorly understood. We have cloned a gene (Mut6) from the unicellular green alga Chlamydomonas reinhardtii that is required for the silencing of a transgene and two transposon families. Mut6 encodes a protein that is highly homologous to RNA helicases of the DEAH-box family. This protein is necessary for the degradation of certain aberrant RNAs, such as improperly processed transcripts, which are often produced by transposons and some transgenes.

Original languageEnglish (US)
Pages (from-to)1159-1162
Number of pages4
JournalScience
Volume290
Issue number5494
DOIs
StatePublished - Nov 10 2000

ASJC Scopus subject areas

  • General

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