TY - JOUR
T1 - Transgenic/knockout mice - tools to study autoimmunity
AU - Mueller, Regula
AU - Sarvetnick, Nora
N1 - Funding Information:
I~. Mueller was supported by fellowships from the Swiss National Science Foundation and the Ciba Geigy Jubliaeumss-tiftung. N Sarvemick was supproted by NIH grants HI) 29764, MH 47680, and HL 48728 and the Diabetes Interdisciplinary Research Program from the Juvenils Diabetes Foundation International.
PY - 1995/12
Y1 - 1995/12
N2 - Transgenic and knockout mice have been valuable tools for clarifying the roles of individual cell types and effector molecules in the pathogenesis of autoimmunity. During the past year, new strains have been added to the large array of transgenic mice, with broad or tissue-specific expression of transgene products. These laboratory models, as well as knockout mice lacking genes for a particular molecule, have greatly enhanced our understanding of autoimmune disease.
AB - Transgenic and knockout mice have been valuable tools for clarifying the roles of individual cell types and effector molecules in the pathogenesis of autoimmunity. During the past year, new strains have been added to the large array of transgenic mice, with broad or tissue-specific expression of transgene products. These laboratory models, as well as knockout mice lacking genes for a particular molecule, have greatly enhanced our understanding of autoimmune disease.
UR - http://www.scopus.com/inward/record.url?scp=0029560319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029560319&partnerID=8YFLogxK
U2 - 10.1016/0952-7915(95)80051-4
DO - 10.1016/0952-7915(95)80051-4
M3 - Article
C2 - 8679123
AN - SCOPUS:0029560319
SN - 0952-7915
VL - 7
SP - 799
EP - 803
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -