Translating efficacy into effectiveness in antiretroviral therapy: Beyond the pill count

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Durable and sustained suppression of HIV replication can be achieved as demonstrated in several recent clinical trials of antiretroviral (ARV) regimens. However, the efficacy demonstrated in the experimental setting does not always translate to effectiveness in the clinical setting. The frequency and number of medications (conventionally referred to as the pill count) contribute to regimen effectiveness. However, clinicians and HIV-infected patients recognise that there are several other characteristics of an ARV regimen that are equally important contributors to its effectiveness. Potency and durability, the potential for drug-drug interactions, and the occurrence of adverse events also contribute to the effectiveness and complexity of a drug regimen. A comprehensive consideration of factors associated with efficacy will optimise the translation to effectiveness for the individual infected with HIV.

Original languageEnglish (US)
Pages (from-to)1969-1979
Number of pages11
JournalDrugs
Volume67
Issue number14
DOIs
StatePublished - 2007

Keywords

  • Antiretrovirals, therapeutic use
  • HIV infections, treatment
  • Lopinavir/ritonavir, therapeutic use

ASJC Scopus subject areas

  • Pharmacology (medical)

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